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 Post subject: Hay Fever
PostPosted: 07 May 2013 15:59 
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Joined: 26 Feb 2013 10:59
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There was a recent article in the Times UK about a new treatment for Hay Fever sufferers. I am sure all the physicians would have heard about it. It is a nasal spray called Dymista.We are informed that it is corticosteroid and antihistamine combined in to a single spray. It is now being used in US and will soon be available in UK. The spray has been approved by NICE. Rave reviews have been given by patients in USA!


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 Post subject: DYMISTA
PostPosted: 08 May 2013 03:49 
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Joined: 24 Mar 2013 02:28
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Dymista: new intranasal rhinitis treatment
01 May 2013,
The nasal spray Dymista is now available for the treatment of perennial and seasonal allergic rhinitis.


Dymista is licensed for use in adults and children 12 years and older at a dose of one spray per nostril twice daily

PHARMACOLOGY
Dymista is a novel combination of two drugs in a nasal spray formulation: fluticasone propionate, a synthetic glucocorticoid, and azelastine, a potent selective H1-antagonist.1

CLINICAL STUDIES
Seasonal allergic rhinitis

The efficacy and safety of the fluticasone/azelastine combination spray in moderate to severe seasonal allergic rhinitis were assessed in 2 randomised, double-blind studies of similar design (n=610 and n=3398). Patients were randomised for twice-daily treatment with the combination nasal spray, fluticasone nasal spray, azelastine nasal spray or placebo (vehicle) for 14 days.2,3

In both studies, the reduction from baseline in total nasal symptom score (comprising nasal congestion, runny nose, itchy nose and sneezing) was significantly greater for the combination spray than for either agent used alone or placebo.2,3

Chronic rhinitis

A further study (n=612) evaluated the safety and efficacy of fluticasone/azelastine in patients with chronic rhinitis (including perennial allergic rhinitis and non-allergic rhinitis) over 12 months using fluticasone as an active control.4

The combination spray resulted in significantly greater nasal symptom relief than fluticasone monotherapy up to week 28. Treatment differences remained consistent to week 52 but significance could not be established owing to decreasing sample sizes.4

Adverse effect profile

The combination spray was well tolerated, with the most commonly reported adverse effects being epistaxis, dysgeusia, dysosmia and headache.
All special pracautions for Antihistamines and Inhaled steroids also need to be considered when prescribing this combination therapy.

G.MOHAN


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